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Stability
Allergenic extracts should be stored in a refrigerator when not in use. The proper storage temperature is 2-8°C (36-46°F). It is recommended to include a recording device in a refrigerator in order to monitor temperature and to note any deviations if they occur. In the event of a power… read moreStability
is reduced with extract dilution. read moreStability
Allergenic extracts should be stored in a refrigerator when not in use. The proper storage temperature is 2-8°C (36-46°F). It is recommended to include a recording device in a refrigerator in order to monitor temperature and to note any deviations if they occur. In the event of a power… read moreStability
As extracts become more dilute their shelf life declines. So when preparing a series of dilutions, it is best to assign shorter dating to the most dilute solutions (>1:1000 v/v) since their potency cannot be guaranteed over time. When making dilutions, use of the diluent Human Serum Albumin (HSA) is… read moreStability
Below is a figure that shows how expiration dating varies by formulation. For standardized products, these dates were established through FDA-approved testing methods. For non-standardized products, these dates were established by the FDA. For more information on extract formulation, please see the section on Extract Formulations Expiration dates for bulk… read moreStability
& Expiration Dating Allergen extracts have a defined expiration which is printed on the product label. The expiration dates assigned have been carefully determined to help minimize potency differences between older and newer lots. As time passes, the allergenic proteins in solution begin to decay, which reduces the potency of the extract. This rate… read moreStability
of the allergenic proteins in solution and therefore the shelf life of the product. The FDA has determined maximum expiration dates for each formulation based on the estimated loss of potency… read moreStability
References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read moreStability
(i.e. its shelf life is much longer than aqueous products). Prior to use, the lyophilized product must be reconstituted (re-hydrated) with an appropriate sterile diluent. read moreCopyright © Extractopedia 2023