Search Results

Dilution Tables Here are some common dilution strategies used when making treatment vials. 5 – Fold Dilution – 5 mL Vials – 1:20 w/v Glycerinated Extract: 1:2 Dilution – 10mL and 5mL Vials: Used for example, when you want to convert a 1:10 w/v into a 1:20 w/v or if you want to convert 10,000… read more

Intradermal Dilutions In early 2013, several allergen extract manufacturers decided to discontinue stock formulations of intradermal products. In place of this, it is recommended that you perform your own dilutions using the extract stock concentrations. Rationale for the discontinuation of intradermal strength products​ Allergen extracts that have been diluted to intradermal strength are known to… read more

Use of Allergen Extracts  >  Mixing Allergens  >  Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Some patients who present as polyallergic may require treatment with a mixture of different clinically relevant allergens. In the United States, it is standard practice to mix multiple allergens into a single treatment vial. This is… read more

Ancillary Supplies Along with your supply of allergen extracts, you will need to stock your clinic with additional supplies to support the practice of immunotherapy. The following is a basic list of products that will be useful for the handling and preparation of your extracts: Sterile empty vials with color-coded vial caps and patient vial… read more

Skin Testing Supplies Once you have reviewed the appropriate procedures, established your diagnostic panel, and ordered your supplies, you are ready to begin testing patients. Most practices will diagnose their patients by skin testing using glycerinated extracts and a sterile, disposable skin test device. Depending on the patient’s clinical history and the allergist’s training and… read more

Shipping & Receiving Extracts All allergen extracts are shipped expedited using a reputable courier under non-refrigerated conditions. It is important to ensure that a member of your staff be available on the day your products are scheduled to arrive to minimize the amount of time the extracts are out of refrigeration. When your supplies arrive,… read more

Expiration Date of a Mix It is important to closely monitor the expiration dates of extracts so that no product is used beyond the assigned date. The manufacturer’s expiration date is the ultimate end date for all materials made from a manufacturer’s concentrate. When mixing extracts, the expiration date of the mix is the same… read more

Formulation Concern – Phenol Does phenol have a negative impact on extract

Stability

? Many extracts contain phenol (0.4%) as a preservative. There have been some reports that phenol can impact the

Stability

of allergenic extracts. However, more recent data has shown that phenol does not appear to have a significant impact on the long term… read more

Diluents & Preservatives When making dilutions from the concentrate vial, a number of diluents can be used. Normal Saline with Phenol (NSP) NSP is the same solution that is used to extract Aqueous extracts. It is a buffered solution of sodium chloride (0.9%) with phenol (0.4%) as a preservative. NSP offers limited

Stability

protection for… read more