Search Results

Anaphylaxis Crash Cart In addition to the recommended routine supplies, every practice that intends to perform allergen immunotherapy must be supplied and trained for possible severe systemic reactions, such as anaphylaxis. Below is a list of recommended emergency supplies that should be stocked separately from the routine supplies. Modifications may be necessary depending on the… read more

Positive & Negative Controls Postive Control – Histamine Since a major physiological component of the allergic response is histamine, it is important to use a histamine reagent to confirm that the patient’s skin has sufficient reactivity to properly interpret the skin test results. In line with this rationale, the histamine positive control can help determine… read more

Intradermal (ID) Intradermal (i.e., intracutaneous) solutions of allergen extracts are available in 10

ml

sterile vials. Since this allergen injection goes deeper than skin prick testing (SPT), it is much more sensitive. Therefore, ID concentrations should be 100- to 1000-fold more dilute than the concentrate, which is used in SPT (e.g., 1:100 to 1:1000 v/v,… read more

Skin Prick Test (SPT) Solutions of allergen extracts used for a Skin prick test (SPT), or percutaneous injections, are available in 5

ml

dropper vials which offer convenience for filling the testing wells of your chosen skin test medical device. Please refer to the product information of your desired skin test device for determining the… read more

How to Perform Dilutions Once you have prepared the patient’s treatment vial (e.g., Red Vial), you will need to perform a series of dilutions before you begin treatment. Subcutaneous allergen immunotherapy begins with a small dose of a highly dilute allergen solution and, over time, increases in volume and concentration until the maintenance dose has… read more

Non-Standardized Extracts Allergenic extracts that are considered non-standardized do not undergo additional laboratory testing to verify relative biologic strength. Instead, non-standardized extracts are assigned potency values based on either the product’s extraction ratio (source material-to-extracting solution) or on an estimated measure of total protein. Weight-to-Volume (w/v): This is simply a ratio of grams of dry… read more

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more

Ordering Supplies When ordering your allergenic extracts, you will be asked to provide some basic information about your requested products. To ensure that your order is accurate and appropriate, you should take into consideration the following: Extract Name Several allergens have similar or identical sounding names (e.g., Pecan tree pollen, Pecan food). Additionally, some allergens… read more