Serum
An outdated term for
Allergen extract
s. In other medical fields, serum refers to blood products, specifically the liquid portion of whole blood, with cellular components and clotting factors removed. read moreShowing Result for: Allergen extract
Phenol
A common preservative in allergenic extracts. Phenol possesses bacteriostatic properties, thereby inhibiting bacterial growth. The FDA mandates that all multiple dose vials contain a preservative to ensure sterility. The inclusion of phenol in patient allergy immunotherapy vials allows for an
Allergen extract
Exemption in USP 797. read moreDiluent
The solution that is used to create dilutions of
Allergen extract
s. Examples of diluents include: human serum albumin (HSA), 50% glycerin and normal saline with phenol (NSP). read moreBAU
BAU, Bioequivalent Allergy Unit. A potency unit used to characterize biological activity of select standardized
Allergen extract
s. BAU was defined using skin prick test titrations in a sensitized patient population. Reference standards were then established by the FDA and utilized by extract manufacturers to maintain the defined relative potency for the specific, standardized extract. This… read moreAqueous
A water-based solution, typically saline-derived. In the case of
Allergen extract
s, aqueous solutions must include a bacteriostatic agent, such as phenol, to maintain sterility. read moreAlum-precipitated
A process whereby an aqueous
Allergen extract
is allowed to complex with an aluminum salt complex (e.g., aluminum hydroxide). Alum-precipitation functions as an adjuvant, which enables the extract to elicit an immunological response. In addition, the alum-allergen complex produces a depot effect, where the allergen is more slowly released into the body. This slow release… read moreIntradermal Dilutions
Intradermal Dilutions In early 2013, several
Allergen extract
manufacturers decided to discontinue stock formulations of intradermal products. In place of this, it is recommended that you perform your own dilutions using the extract stock concentrations. Rationale for the discontinuation of intradermal strength productsAllergen extract
s that have been diluted to intradermal strength are known to… read moreMixing Concerns: Cross-Reactivity & Proteolytic Enzymes
Use of
Allergen extract
s > Mixing Allergens > Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Some patients who present as polyallergic may require treatment with a mixture of different clinically relevant allergens. In the United States, it is standard practice to mix multiple allergens into a single treatment vial. This is… read moreUSP 797 Compounding Guidelines
USP 797 Compounding Guidelines Beyond Use Dating – 28 Day Shelf Life for Compounded Products? There has been some controversy over applying the United States Pharmacopeia (USP) shelf-life rules for compounded pharmaceutical products to
Allergen extract
mixes. These rules require that all compounded (mixed) materials be disposed of every 28 days due to sterility concerns.… read moreAseptic Procedures & Sterility
Aseptic Procedures & Sterility Even though it is an FDA requirement that
Allergen extract
s contain a preservative agent (e.g. phenol), it is essential to utilize aseptic techniques when preparing patient treament vials. When working withAllergen extract
s it is important to use a dedicated workspace that is clean and free of clutter. It is also… read more