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Use of Allergen Extracts  >  Mixing Allergens  >  Mixing Concerns:

Cross-reactivity

& Proteolytic Enzymes Mixing Concerns:

Cross-reactivity

& Proteolytic Enzymes Some patients who present as polyallergic may require treatment with a mixture of different clinically relevant allergens. In the United States, it is standard practice to mix multiple allergens into a single treatment vial. This is… read more

Cross-reactivity

Among Non-Plant Allergens While patterns of

Cross-reactivity

are clear among many plants, this pattern may not be as obvious among other types of allergens.

Cross-reactivity

among mammalian or insect species is not well-defined. Certain allergenic proteins (e.g. albumin, lipocalin, tropomyosin) may contribute to

Cross-reactivity

in some patients. Tropomysoin, for example, is a protein found… read more

Importance of

Cross-reactivity

Closely related allergen species often exhibit some degree of

Cross-reactivity

. In general, plant species within the same taxonomic family may be substantially, though not completely, cross-reactive. Additionally, there are several allergenic proteins which are common across unrelated species known as “pan-allergens”. For some patients, these proteins can generate an IgE immune response… read more

Home  >  Latest Topics Mixing Concerns:

Cross-reactivity

& Proteolytic Enzymes Use of Allergen Extracts  >  Mixing Allergens  >  Mixing Concerns:

Cross-reactivity

& Proteolytic Enzymes Mixing Concerns:

Cross-reactivity

& Proteolytic Enzymes Some patients who present with numerous sensitivities may require treatment with a mixture of different allergens. In the United States, it is standard practice to mix… read more

Home  >  Popular Topics Extract Formulations Extract Formulations Allergen extracts are available in a variety of formulations. An extract’s formulation directly impacts the stability of the allergenic proteins in solution and therefore the shelf life of the product. The FDA has determined maximum expiration dates for each formulation based on the estimated loss of potency… read more

Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens

Cross-reactivity

Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more

Mixing Allergens Once you have interpreted the skin test results and decided to prescribe subcutaneous allergen immunotherapy, the next step is to create the patient’s treatment vials. This can either be ordered directly from ALK as a patient treatment set or mixed in your office from bulk concentrates. As you begin to mix individual treatment… read more

Profilin & Pan-Allergens

Cross-reactivity

is often seen between unrelated species due to shared minor allergens such as Profilin. A minor allergen is an allergenic protein that has demonstrated clinical sensitivity in a minority of patients in a population. Common allergens that demonstrate clinical sensitivity across unrelated species are known as Pan-Allergens. Profilin is a structual… read more

Oral Allergy Syndrome Many common food allergens are cross-reactive with unrelated (or distantly related) pollen allergens, such as Apple with Birch, or Melon with Ragweed. This is because they share evolutionarily conserved protein structures that have a similar function across species. For example, the major allergen, Bet v 1, found in Birch, is an essential… read more