ml
A milliliter. One thousandth of a liter.
read more
Showing Result for: ml
Latest Topics
Home > Latest Topics Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Use of Allergen Extracts > Mixing Allergens > Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Mixing Concerns: Cross-Reactivity & Proteolytic Enzymes Some patients who present with numerous sensitivities may require treatment with a mixture of different allergens. In the United States, it is standard practice to mix…
read more
Popular Topics
Home > Popular Topics Extract Formulations Extract Formulations Allergen extracts are available in a variety of formulations. An extract’s formulation directly impacts the stability of the allergenic proteins in solution and therefore the shelf life of the product. The FDA has determined maximum expiration dates for each formulation based on the estimated loss of potency…
read more
W/V
w/v, weight to volume. A ratio of the weight of dry raw material per volume of extracting fluid, expressed in grams per
ml
or kg per L. For example, 1:10 w/v implies that one gram of dry allergenic material (e.g. pollen) was extracted in 10ml
of extracting solution. A 1:20 w/v extract is half… read moreAnaphylaxis
An immediate, severe hypersensitivity reaction caused by a systemic (full body) allergic response. One or more of the following symptoms may occur: sneezing, mild to severe generalized urticaria, itching (other than at the skin test site), extensive or generalized edema, wheezing, asthma, dyspnea, cyanosis, hypotension, syncope, and upper airway obstruction. Symptoms may progress to shock…
read more
Term & Conditions
Terms of Use ALK Terms of use ALK operates certain websites (“Website”) for personal information and education purposes. By visiting our Website, or by registering as a user of the on-line services that we provide, you agree to these Terms of Use and to our Privacy Policy, as they may be amended from time to…
read more
Dilution Tables
Dilution Tables Here are some common dilution strategies used when making treatment vials. 5 – Fold Dilution – 5
ml
Vials – 1:20 w/v Glycerinated Extract: 1:2 Dilution – 10ml
and 5ml
Vials: Used for example, when you want to convert a 1:10 w/v into a 1:20 w/v or if you want to convert 10,000… read moreDose Calculations for the Maintenance Vial
Dose Calculations for the Maintenance Vial Theformulabelowoffersasimplifiedmethodforcalculatingthevolumeofan extract to add based on the target dose selected. Importantly, thiscalculationcanbeusedforanypotencyunit(AU, BAU, PNU, w/v, or µg). V = 10T/E V: Volume to be drawn up from the manufacturer’s bulk concentrate and added to the patient’s vial T: Target maintenance dose in 0.5cc injection (e.g., 2000BAU, 1000PNU, 7.5µg Der…
read more
Analytical Method – ID50EAL (“IDEAL 50”)
Analytical Method – ID50EAL (“IDEAL 50”) Standardized potency values were established by a skin test titration study (ID50EAL) using a limited number of patients. “ID50EAL” is an acronym for “Intradermal Dilution for 50 mm sum of Erythema determines the bioequivalent ALlergy units.” This study measured the size of the erythema in allergic patients receiving a…
read more
Quality Concern – Coring
Quality Concern – Coring Coring occurs when pieces of the vial’s rubber stopper break off and fall into the extract due to repeated syringe insertion. These pieces appear as small grey or dark particles that float around the vial. These are not to be confused with protein precipitates, which typically appear as light-colored particles. Regarding…
read more