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Formulation Concern –

Phenol

Does

Phenol

have a negative impact on extract stability? Many extracts contain

Phenol

(0.4%) as a preservative. There have been some reports that

Phenol

can impact the stability of allergenic extracts. However, more recent data has shown that

Phenol

does not appear to have a significant impact on the long term… read more

Intradermal Dilutions In early 2013, several allergen extract manufacturers decided to discontinue stock formulations of intradermal products. In place of this, it is recommended that you perform your own dilutions using the extract stock concentrations. Rationale for the discontinuation of intradermal strength products​ Allergen extracts that have been diluted to intradermal strength are known to… read more

USP 797 Compounding Guidelines Beyond Use Dating – 28 Day Shelf Life for Compounded Products? There has been some controversy over applying the United States Pharmacopeia (USP) shelf-life rules for compounded pharmaceutical products to allergen extract mixes. These rules require that all compounded (mixed) materials be disposed of every 28 days due to sterility concerns.… read more

Aseptic Procedures & Sterility Even though it is an FDA requirement that allergen extracts contain a preservative agent (e.g.

Phenol

), it is essential to utilize aseptic techniques when preparing patient treament vials. When working with allergen extracts it is important to use a dedicated workspace that is clean and free of clutter. It is also… read more

Anaphylaxis Crash Cart In addition to the recommended routine supplies, every practice that intends to perform allergen immunotherapy must be supplied and trained for possible severe systemic reactions, such as anaphylaxis. Below is a list of recommended emergency supplies that should be stocked separately from the routine supplies. Modifications may be necessary depending on the… read more