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Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more

Intradermal Dilutions In early 2013, several allergen extract manufacturers decided to discontinue stock formulations of intradermal products. In place of this, it is recommended that you perform your own dilutions using the extract stock concentrations. Rationale for the discontinuation of intradermal strength products​ Allergen extracts that have been diluted to intradermal strength are known to… read more

Positive & Negative Controls Postive Control – Histamine Since a major physiological component of the allergic response is histamine, it is important to use a histamine reagent to confirm that the patient’s skin has sufficient reactivity to properly interpret the skin test results. In line with this rationale, the histamine positive control can help determine… read more

Ancillary Supplies Along with your supply of allergen extracts, you will need to stock your clinic with additional supplies to support the practice of immunotherapy. The following is a basic list of products that will be useful for the handling and preparation of your extracts: Sterile empty vials with color-coded vial caps and patient vial… read more

Effect of Dilution on Stability As extracts become more dilute their shelf life declines. So when preparing a series of dilutions, it is best to assign shorter dating to the most dilute solutions (>1:1000 v/v) since their potency cannot be guaranteed over time. When making dilutions, use of the diluent Human Serum Albumin (

HSA

) is… read more

Diluents & Preservatives When making dilutions from the concentrate vial, a number of diluents can be used. Normal Saline with Phenol (NSP) NSP is the same solution that is used to extract Aqueous extracts. It is a buffered solution of sodium chloride (0.9%) with phenol (0.4%) as a preservative. NSP offers limited stability protection for… read more

Selecting Allergen Extracts Choosing which allergen extracts to use in your practice can be challenging. There are many factors to consider depending on whether you are designing a diagnostic panel for skin testing, selecting the most representative allergens for treatment, or even just figuring out how to order the products and store them properly. Additionally,… read more