Diluent
The solution that is used to create dilutions of allergen extracts. Examples of
Diluent
s include: human serum albumin (HSA), 50% glycerin and normal saline with phenol (NSP). read moreShowing Result for: Diluent
Diluents & Preservatives
Diluent
s & Preservatives When making dilutions from the concentrate vial, a number ofDiluent
s can be used. Normal Saline with Phenol (NSP) NSP is the same solution that is used to extract Aqueous extracts. It is a buffered solution of sodium chloride (0.9%) with phenol (0.4%) as a preservative. NSP offers limited stability protection for… read moreReferences
Home > References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.…
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Reconstituted
Rehydrate freeze-dried (lyophilized) product with sterile
Diluent
. read moreLyophilized
Freeze-dried. A manufacturing process where water is removed from a product in a controlled environment. The resulting product is a dry, flaky material of high stability (i.e. its shelf life is much longer than aqueous products). Prior to use, the lyophilized product must be reconstituted (re-hydrated) with an appropriate sterile
Diluent
. read moreHSA
HSA, Human Serum Albumin. A chemically-fractioned component of blood that may be added to
Diluent
s to increase allergen stability. The albumin coats the interior wall of the glass vial, preventing allergenic proteins from adhering. Additionally, albumin stabilizes protein aggregation, thereby promoting protein stability. This stabilizingDiluent
can be used to maintain potency when dilutions are… read moreIntradermal Dilutions
Intradermal Dilutions In early 2013, several allergen extract manufacturers decided to discontinue stock formulations of intradermal products. In place of this, it is recommended that you perform your own dilutions using the extract stock concentrations. Rationale for the discontinuation of intradermal strength products Allergen extracts that have been diluted to intradermal strength are known to…
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Safety Concern – Latex in Rubber Stoppers
Safety Concern – Latex in Rubber Stoppers ALK rubber stoppers are made of gray butyl synthetic rubber, but contain a small percentage of natural rubber, which may theoretically contain latex allergens that could interfere with proper diagnosis in latex- sensitive patients. n research that evaluated the potential effect of latex in rubber stoppers on allergenic…
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Positive & Negative Controls
Positive & Negative Controls Postive Control – Histamine Since a major physiological component of the allergic response is histamine, it is important to use a histamine reagent to confirm that the patient’s skin has sufficient reactivity to properly interpret the skin test results. In line with this rationale, the histamine positive control can help determine…
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Ancillary Supplies
Ancillary Supplies Along with your supply of allergen extracts, you will need to stock your clinic with additional supplies to support the practice of immunotherapy. The following is a basic list of products that will be useful for the handling and preparation of your extracts: Sterile empty vials with color-coded vial caps and patient vial…
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