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Antigen

Any natural or synthetic substance capable of eliciting a cellular-signaling response. All allergens are

Antigen

s, but the reverse is not true.

Antigen

s bind different classes of Ig receptors (e.g., IgA, IgG, IgM, IgE). Allergens specifically provoke an IgE antibody response (Type I hypersensitivity) in sensitized individuals, while non-sensitized individuals clear the allergen, typically symptom-free, via… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

References

Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Major allergen

An allergenic protein that has been found to be clinically significant in over 50% of a population of patients allergic to that particular allergen. Major allergens have been characterized for a number of allergenic species. Common examples of major allergens include: Amb a 1 (Ragweed), Fel d 1 (Cat), Phl p 5 (Timothy grass), etc.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Allergen

Any natural or synthetic

Antigen

(usually a protein) that is capable of producing an IgE-mediated immune response. All allergens are

Antigen

s, but not all

Antigen

s are allergens. Allergens specifically elicit an IgE antibody response (Type I hypersensitivity), while an

Antigen

can elicit any kind of antibody response (such as IgG). read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Cross-Reactivity Among Non-Plant Allergens

Cross-Reactivity Among Non-Plant Allergens While patterns of cross-reactivity are clear among many plants, this pattern may not be as obvious among other types of allergens. Cross-reactivity among mammalian or insect species is not well-defined. Certain allergenic proteins (e.g. albumin, lipocalin, tropomyosin) may contribute to cross-reactivity in some patients. Tropomysoin, for example, is a protein found… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Standardized Extracts

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.