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Major Allergen Characterization The active ingredients of allergenic extracts are the proteins that the immune system responds to. Within an extract, there may be multiple allergenic proteins. Major allergens are those proteins to which at least 50% of a population are sensitized to. Some of these allergens, such as Fel d 1 in cat, are… read more

Non-Standardized Extracts Allergenic extracts that are considered non-standardized do not undergo additional laboratory testing to verify relative biologic strength. Instead, non-standardized extracts are assigned potency values based on either the product’s extraction ratio (source material-to-extracting solution) or on an estimated measure of total protein. Weight-to-Volume (

W/V

): This is simply a ratio of grams of dry… read more

Standardized Extracts The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between lots and manufacturers of the same extract. Extracts that have been standardized by the FDA include the northern pasture grasses (Timothy, June, Meadow Fescue, Orchard, Redtop, Perennial Rye, Sweet… read more

Potency Labeling The biologic strength (potency) of an allergenic extract can be expressed in a variety of ways. In general, all allergenic extracts are divided into 2 categories: Standardized (BAU /AU) The FDA has mandated standardization testing for a limited number of extracts. The purpose of standardization is to minimize the amount of variability between… read more