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W/V

W/V

, weight to volume. A ratio of the weight of dry raw material per volume of extracting fluid, expressed in grams per mL or kg per L. For example, 1:10

W/V

implies that one gram of dry allergenic material (e.g. pollen) was extracted in 10 mL of extracting solution. A 1:20

W/V

extract is half… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

References

Home  >  References References General References Used Throughout Stability References Painful Injection From 50% Glycerin FDA Standardization Major Allergen And Standardization Regional Relevance Of Allergens Cross-Reactivity Management Of Anaphylaxis Coring & Syringe Technique Skin Testing USP 797 References – Beyond Use Date, Pharmacy Compounding Rules Allergen Information General References Used Throughout Cox, L, et al.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Dose Calculations for the Maintenance Vial

Dose Calculations for the Maintenance Vial Theformulabelowoffersasimplifiedmethodforcalculatingthevolumeofan extract to add based on the target dose selected. Importantly, thiscalculationcanbeusedforanypotencyunit(AU, BAU, PNU,

W/V

, or µg). V = 10T/E V: Volume to be drawn up from the manufacturer’s bulk concentrate and added to the patient’s vial T: Target maintenance dose in 0.5cc injection (e.g., 2000BAU, 1000PNU, 7.5µg Der… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Anaphylaxis Crash Cart

Anaphylaxis Crash Cart In addition to the recommended routine supplies, every practice that intends to perform allergen immunotherapy must be supplied and trained for possible severe systemic reactions, such as anaphylaxis. Below is a list of recommended emergency supplies that should be stocked separately from the routine supplies. Modifications may be necessary depending on the… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Dosing

Dosing One of the primary objectives when mixing allergenic extracts is to prepare a patient’s treatment set in a way that ensures an optimal therapeutic dose of each allergen in the patient’s allergen extract vial. Therefore, the limiting step when mixing is deciding what volume of each allergen to add to a patient’s maintenance vial.… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.

Effect of Formulation on Stability

Effect of Formulation on Stability Below is a figure that shows how expiration dating varies by formulation. For standardized products, these dates were established through FDA-approved testing methods. For non-standardized products, these dates were established by the FDA. For more information on extract formulation, please see the section on Extract Formulations Expiration dates for bulk… read more 705357C1-B577-4332-A248-2D41FB183786Created with sketchtool.